--- a/management/univention-appcenter/python/appcenter/app.py	
+++ a/management/univention-appcenter/python/appcenter/app.py	
@@ -1001,7 +1001,7 @@ def _load_pickle_cache(cls):
 			try:
 				with open(pickle_file, 'rb') as fd:
 					return load(fd)
-			except (IOError, PickleError):
+			except (EOFError, EnvironmentError, PickleError):
 				return None
 
 	@classmethod